Effect of methylene blue on intra-abdominal adhesion formation in rats

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Effect of methylene blue on intra-abdominal adhesion formation in rats.

BACKGROUND Adhesion formation represents an important clinical challenge in gastro-intestinal surgery. In the late era, methylene blue (MB) has been claimed to play a helping role in combating such a problem. In the present study, we investigated the effects of MB administered intraperitoneally on the surgically-induced adhesions in rats and tried to clarify whether its impact is concentration-...

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Peritoneal adhesions are challenging in abdominal surgery. In spite of different kinds of treatments still no definitive and effective treatment is suggested. To determine the prevention effects of intraperitoneal (ip) methylene blue in post surgical adhesion formation 44 rabbits were randomly divided in two groups of equal number. Group I received an intra peritoneal injection of a 1% suspensi...

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The effect of methylene blue on peritoneal adhesion formation.

BACKGROUND/AIMS Postoperative adhesions following abdominopelvic surgery may cause significant morbidity. In this study, the effect of different doses of methylene blue in the formation of adhesions and the role of allopurinol in revealing the possible mechanism of action was evaluated. METHODS Seventy five male Wistar-Albino rats weighing 200g-220g. were divided into five groups of 15 rats e...

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ژورنال

عنوان ژورنال: International Journal of Surgery

سال: 2008

ISSN: 1743-9191

DOI: 10.1016/j.ijsu.2008.08.004